Genome-Wide 5-mC & 5-hmC Sequencing Guide
It is now well established that the classic genetic code is not sufficient to explain many complex phenotypes and causes of human diseases. Epigenetic modifications to DNA, such as methylcytosine (5-mC) and hydroxymethylcytosine (5-hmC), must also be considered as they can have profound effects on gene expression and are important for nearly every aspect of biology. These modifications can be stable, inheritable, and passed on to future generations.
Recent advances in sample preparation, high-throughput sequencing, and bioinformatics, now give researchers looking to study DNA methylation and hydroxymethylation several options for investigating these epigenetic modifications on a genome-wide scale. Zymo Research offers a comprehensive suite of epigenetic services, including multiple platforms for 5-mC and 5-hmC analysis for focused, mid-tier, and whole-genome interrogations. Additional services, such as ChIP-Seq and RNA-Seq, are also available.
With the help of their friends at Epigenie, the scientists at Zymo Research have recently created a guide to help researchers get started and take the plunge into genome-wide epigenetic analysis. Click here to read the complete guide for Getting Started with Genome-Wide 5-mC & 5-hmC Sequencing.