DNA Methylation and HydroxymethylationTools & Technology

Genome-Wide 5-mC & 5-hmC Sequencing Guide

servicesIt is now well established that the classic genetic code is not sufficient to explain many complex phenotypes and causes of human diseases. Epigenetic modifications to DNA, such as methylcytosine (5-mC) and hydroxymethylcytosine (5-hmC), must also be considered as they can have profound effects on gene expression and are important for nearly every aspect of biology. These modifications can be stable, inheritable, and passed on to future generations.

Recent advances in sample preparation, high-throughput sequencing, and bioinformatics, now give researchers looking to study DNA methylation and hydroxymethylation several options for investigating these epigenetic modifications on a genome-wide scale. Zymo Research offers a comprehensive suite of epigenetic services, including multiple platforms for 5-mC and 5-hmC analysis for focused, mid-tier, and whole-genome interrogations. Additional services, such as ChIP-Seq and RNA-Seq, are also available.

With the help of their friends at Epigenie, the scientists at Zymo Research have recently created a guide to help researchers get started and take the plunge into genome-wide epigenetic analysis.  Click here to read the complete guide for Getting Started with Genome-Wide 5-mC & 5-hmC Sequencing.


Previous post

You can take a gene out of context, but can you take context out of a gene?

Next post

Put down that water bottle! BPA Exposure Alters Epigenetic Profile in Neurons

Kevin B.

Kevin B.

Kevin grew up in Northern California and has also spent several years living on the East Coast. When he is not in the lab, Kevin enjoys snowboarding, watching NFL games (and playing fantasy football!), spending time outdoors, and exploring Southern California.