DNA Methylation and HydroxymethylationTools & Technology

Epigenetics for All! New Tools Available for Genome-Wide Epigenetic Analysis

Zymo Research Corporation, The Epigenetics Company, recently expanded their services for genetic, epigenetic, and expression analysis.  As one of the pioneers in the field and with over a decade of experience in epigenetics research, Zymo Research started offering unique services for genome-wide DNA methylation analysis two years ago.  Since then, they have continued to expand their epigenetic analysis capabilities and are now the most established and complete provider of epigenetic services.  In addition to offering services for investigating DNA methylation (5-mC) and hydroxymethylation (5-hmC), they are now offering targeted DNA methylation analysis via next-gen sequencing (NGS) for interrogation of multiple loci or multiple samples, or both!  Several service options are available for DNA methylation analysis for the varying levels of genome coverage – there is a solution for any project size and scope.  Their service scientists offer a free consultation to help customers determine the best option for each unique project.  Zymo Research’s epigenetic services make genome-wide analyses affordable for nearly every budget.  No experience with sequencing or bioinformatics technologies is required – simply submit the samples and receive high quality, easy-to-interpret publication-ready data and figures.

There are many reasons to choose Zymo Research for Epigenetic Service, the first of which is that they start with the most trusted and most highly-cited bisulfite conversion chemistry.  In addition, they offer novel library preparation workflows for ultra-low DNA inputs, can work with samples from any organism with a reference genome, and utilize highly specialized bioinformatics pipelines for seamless data handling, analysis, and delivery.  Furthermore, the scientists at Zymo Research have recently developed a novel technique to determine DNA hydroxymethylation levels on a genomic scale called Reduced Representation Hydroxymethylation Profiling (RRHP).  RRHP, a service offered exclusively by Zymo Research, is the only method available for reliable single-site resolution and strand-specific profiling of 5-hmC modifications in DNA.  Additional services are also available for genetic, epigenetic, and expression analysis, including 5-hmC CapSeq, ChIP-Seq, nucleosome position mapping, RNA-Seq, targeted DNA sequencing, large and small genome sequencing, mitochondrial DNA sequencing, and analysis of DNA modifications by mass spectrometry.  These services can be combined and customized to meet the needs of the researcher depending on the requirements of any particular study.

These NGS-based technologies are no longer reserved for the labs with huge grants, unlimited resources, and bioinformatics cores on retainer.  Epigenetics services from Zymo Research are something that even small labs can afford and are the best option out there for exploratory/discovery type experiments, especially when just starting to look at epigenetics for the first time.  This marks the beginning of a new era in epi-biomarker discovery and validation that will aid in the diagnostics and prognostics of human diseases, and facilitate personalized medicine and companion diagnostics to optimize the efficiency of individualized drug treatment.  So, whether you are trying to look for differentially methylated regions between a control sample and treated sample or if you are trying to determine the effect of a mouse diet on the epigenetics of its intestinal cells, Zymo Research has a service solution for you.

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Starting from Scratch: DNA Methylation Marks Erased Through 5-hmC in Primordial Germ Cells

Ron L.

Ron L.

Ron was born and raised in Southern California. He goes surfing every chance he gets and loves living so close to the ocean. Ron also enjoys action movies and can’t wait for Expendables 3 to come out!