DNA methylation dynamics
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

The Same, Only Different: DNA Methylation Dynamics in the Human Genome

DNA methylation is one of the most common, and most studied, epigenetic modifications.  DNA methylation plays a central role in the development and differentiation of mammalian cells, and when DNA methylation is misregulated, it can lead to many different types of human diseases, including cancer and neurological disorders.  DNA methylation, …

DNA Methylation and HydroxymethylationTools & Technology

Epigenetics for All! New Tools Available for Genome-Wide Epigenetic Analysis

Zymo Research Corporation, The Epigenetics Company, recently expanded their services for genetic, epigenetic, and expression analysis.  As one of the pioneers in the field and with over a decade of experience in epigenetics research, Zymo Research started offering unique services for genome-wide DNA methylation analysis two years ago.  Since then, …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

A new web-based tool for high-throughput DNA methylation pathway analysis of multiple cancer types

Global cytosine hypomethylation and promoter hypermethylation are characteristic in cancer, but how DNA methylation targets biological pathways and gene sets is unclear. It is hypothesized that during tumorigenesis certain pathways and gene sets are commonly dysregulated via DNA methylation across cancer types. A logistic regression-based gene set enrichment method called …

Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

To Nurse or To Forage? DNA Methylation Defines Honeybee Behavior

A honeybee society is organized into distinct castes, where a male embryo becomes a drone and a female embryo can develop into a queen or worker. While a queen’s role is to reproduce, the behavior of a worker varies throughout its lifetime. A worker’s first role is to act as …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Does Epigenetics Control Aging? New study finds DNA methylation patterns change with age

Aging is a natural part of life, but many of the molecular details that contribute to the aging process remain unclear and cannot be explained by classical genetics.  There are several age-related DNA methylation biomarkers, suggesting that epigenetics is involved in aging, but until recently there has not been a …