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Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

Using DNA Methylation to Diagnosis Type 2 Diabetes

Type 2 diabetes is mainly seen in genetically predisposed individuals exposed to non-genetic risk factors like obesity, age and physical inactivity. Lately, it has become evident that this interaction between genetic and environmental factors most likely involves epigenetic modifications. Rönn & Ling recently summarized human data supporting a role for …

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Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsUncategorized

Early-life Exposure to Substance Abuse and the Risk for Type 2 Diabetes

Type 2 diabetes (T2D) is a chronic non-communicable disease that generally develops after the age of 40 and therefore believed to be associated with aging. There is, however,increasing experimental and epidemiological evidence that risk of T2D and obesity which is an important risk factor for T2D may be epigenetically programmed during critical windows …

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Aging, Environment, & DiseaseImprinting and Inheritance

Increased risk of insulin resistance in rat offsprings exposed prenatally to white rice

Mustapha Umar Imam1, Maznah Ismail1,2 1 Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia; emails: mustyimam@gmail.com,  maznahis@upm.edu.my; fax +603-8947-2116. 2 Department of Nutrition and Dietetics, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia   Dietary factors and habits are …

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Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

Silencing Diabetes

While Type 1 diabetes (T1D) is an autoimmune disorder characterized by the destruction of pancreatic cells, Type 2 (T2D) is defined as deficient insulin production and impaired insulin action. This is why the two can be distinguished from each other through an antibody screening. The exact cause of β cell …

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