Skeletal muscles affected by FSHD
Aging, Environment, & DiseaseRegulatory RNA

Epigenetic regulation of a non-coding RNA implicated in FSHD pathogenesis

Facioscapulohumeral muscular dystrophy (FSHD) is a common and debilitating myopathy very frequently associated with decreased D4Z4 repetitive element copy number at chromosome 4q35. The exact molecular mechanism driving FSHD is unknown, however, epigenetic dysregulation is suspected to be a major contributing factor.

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