Regulatory RNA

Enhancer RNAs as molecular traps

Results from ENCODE released in 2007 suggested that 80% of the human genome plays a role in at least one RNA biochemical and/or chromatin modelling event; much higher than previously understood. More importantly, a significant portion of this active genome is transcribed into RNA, without any known corresponding functional protein. …

Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Gene Transcription: Not Always Dictated by Histone Modifications!

The proper regulation of gene expression is of fundamental importance in the maintenance of normal growth and development.  Misregulation of genes can lead to such outcomes as cancer, diabetes and neurodegenerative disease.  A key step in gene regulation occurs during the transcription of the chromosomal DNA into messenger RNA by …