Predicting Double-Strand Breaks
Tools & Technology

Accurately Predicting Double-Strand Breaks Using Public Genetic Databases

Double-strand breaks (DSBs) cause chromosomal rearrangements, such as deletions, translocations, and fusions of DNA [1]. This results in a host of issues with cellular function, making it important to map where DSBs can occur in the genome. Mourad et al used public data on the epigenome, chromatin structure, DNA motifs, …

Chromatin StructureDevelopmental Biology & Stem CellsRegulatory RNA

Role Reversal: Are Transcription Factors Responsible for Heterochromatin Formation?

Regions of eukaryotic chromosomes are classified into two distinct groups: euchromatin, which is generally less compacted and contains actively transcribed genes, and heterochromatin, which is typically more compacted and contains silent genes and the majority of the repeated DNA elements.  Transcription factors are generally thought of as proteins that are …