5hmc
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Starting from Scratch: DNA Methylation Marks Erased Through 5-hmC in Primordial Germ Cells

A growing body of evidence indicates that ancestral environmental factors can influence the physiology and behavior of the offspring, a process known as epigenetic inheritance. However, in each generation the epigenetically inherited modifications are thought to be erased in cells called primordial germ cells (PGCs), the precursors to sperm and …

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asdf
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Here today, gone tomorrow: The Genome-Wide Absence of 5-hmC in Melanomas

Melanoma is an aggressive form of skin cancer that occurs at a higher frequency with increasing age, in addition to environmental contributions, such as exposure to UV light. In fact, it accounts for 75% of all skin cancers and occurs more commonly in women than men. Melanoma tumors were previously …

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5mC and 5hmC
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Maternal instincts: Protection of 5mC?

DNA modification by 5-methylcytosine (5mC) was the only recognized DNA modification for many years in mammals and 5mC plays important roles in cell differentiation and development. Recently, a novel 5-hydroxymethylcytosine (5hmC) DNA modification has been reported and the balance between 5mC and 5hmC in the genome is a critical step …

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5mc to 5hmc
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Potential of 5-hmC and TET Expression as Cancer Biomarkers

The role of epigenetics in cancer and developmental biology has become the focus of extensive research. 5-hydoxymethylcytosine (5-hmC) is an epigenetic modification that arises from the oxidation of 5-methylcytosine (5-mC) by the epigenetic regulatory proteins belonging to the TET (ten-eleven translocation) family of α-ketoglutarate-dependent deoxygenases.  The TET enzymes are responsible …

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