DNA Methylation and Immune Cell Differentiation
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

DNA Methylation Regulates Differentiation of Naive Immune Cells into Effector Cells

During an adaptive immune response, naive CD8 T cells differentiate into antigen-specific effector cells that release cytotoxic proteins and rapidly proliferate to kill infected cells. When the pathogen has cleared, the majority of effector cells undergo apoptosis while a selected pool becomes memory cells. The differentiation process from naive to …

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