Endothelial DNA Methylation Goes With the Flow
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Endothelial DNA Methylation Goes With the Flow

Atherosclerosis is an inflammatory disease of the arterial walls, and is the major cause of heart attack and stroke. Atherosclerosis is localized to curves and branches in the vasculature where disturbed blood flow (d-flow) is able to alter gene expression and induce endothelial cell (EC) dysfunction. Our lab’s work focuses …

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Epigenetic Effects of Folic Acid on Development
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Maternal Diet Affects DNA Methylation Patterns in Offspring

There is now mounting evidence that diet and other environmental factors can have widespread and long-lasting influences on a developing fetus. Historically, folic acid supplementation is recommended to pregnant mothers as a means to prevent developmental disorders and birth defects. However, there is still no clear understanding how such supplementation …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mysterious Mechanism of Multiple Myeloma Explained by Epigenetics

If you are trying to understand an enemy so you can battle them more effectively, it is usually best to know as much as you can about them, including where they are attacking from.  A timely example, considering the upcoming Independence Day holiday on the 4th of July, is the …

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Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Epigenetic reprogramming key to normal development

Somatic cell nuclear transfer (SCNT) defines the process in which a somatic cell’s nucleus is removed and then introduced into an enucleated oocyte, or egg cell. Following transfer, the nucleus is reprogrammed by factors in the oocyte such that it now possesses the ability to mitotically divide and form totipotent …

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