Losing Heterochromatin to Determine Cell Fate
Chromatin StructureDevelopmental Biology & Stem Cells

Losing Heterochromatin to Determine Cell Fate

In the moments after fertilization, the tiny mass that is the embryo sets in motion developmental programs that will transform it into a human being. One of the earliest steps in human development is the formation of the germ layers. Humans and other animals in the Chordata phylum, have three …

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5-methylcytosine (5-mC) in RNA
Developmental Biology & Stem CellsRegulatory RNA

5-Methylcytosine in RNA is More Common and Widespread than Previously Known!

The existence of 5-methylcytosine (5-mC) in nucleic acid has been known for more than 50 years, and the majority of research in the past has focused on 5-mC in DNA. However, 5-mC is also present in RNA and interest in this RNA modification has been increasing in recent years. To …

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services
DNA Methylation and HydroxymethylationTools & Technology

Genome-Wide 5-mC & 5-hmC Sequencing Guide

It is now well established that the classic genetic code is not sufficient to explain many complex phenotypes and causes of human diseases. Epigenetic modifications to DNA, such as methylcytosine (5-mC) and hydroxymethylcytosine (5-hmC), must also be considered as they can have profound effects on gene expression and are important …

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miRNA_3
Developmental Biology & Stem CellsRegulatory RNA

Soaking up the Competition – Circular RNAs as Molecular Sponges for miRNAs

Numerous families of non-coding RNAs have been identified in mammalian cells, including lncRNA, miRNA, siRNA, and piRNA.  Another type of RNA called circular RNA (circRNA) has remained a mysterious class, as the exact function of these molecules has not been described. Usually, circRNAs result from spicing events and have been …

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pelican2
DNA Methylation and HydroxymethylationTools & Technology

Epigenetics for All! New Tools Available for Genome-Wide Epigenetic Analysis

Zymo Research Corporation, The Epigenetics Company, recently expanded their services for genetic, epigenetic, and expression analysis.  As one of the pioneers in the field and with over a decade of experience in epigenetics research, Zymo Research started offering unique services for genome-wide DNA methylation analysis two years ago.  Since then, …

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Brown Mouse
Regulatory RNA

RNA methylation recently found to be a widespread epigenetic modification

DNA methylation is one of the most important and most intensively studied areas of epigenetic regulation.  However, there is not much known about the methylation of RNA molecules and whether RNA methylation is an epigenetic mechanism to regulate gene expression or other cellular processes.  RNA can be methylated at the …

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