Ribosome
Aging, Environment, & DiseaseRegulatory RNA

Live long and prosper: Specialized ribosomes counteract ageing

Markus Schosserer and Johannes Grillari University of Natural Resources and Life Sciences, Vienna Department of Biotechnology Muthgasse 18 1190 Vienna Austria johannes.grillari@boku.ac.at   A team of Austrian researchers discovered that the novel gene NSUN5, one of the few highly conserved genes modulating longevity, is able to influence the aging process …

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RNA methylation, stem cell differentiation, and RNA stability
Developmental Biology & Stem CellsRegulatory RNA

RNA Methylation: The Next Big Thing in Stem Cell Differentiation and RNA Stability

While DNA methylation is probably the longest studied and best understood epigenetic modification, methylation of RNA is gaining increased appreciation, especially recently.  N6-methyladenosine (m6A) in RNA has been observed to be the most frequently occurring epigenetic modification in mRNAs in eukaryotic organisms, but the function of this modification is still …

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5-methylcytosine (5-mC) in RNA
Developmental Biology & Stem CellsRegulatory RNA

5-Methylcytosine in RNA is More Common and Widespread than Previously Known!

The existence of 5-methylcytosine (5-mC) in nucleic acid has been known for more than 50 years, and the majority of research in the past has focused on 5-mC in DNA. However, 5-mC is also present in RNA and interest in this RNA modification has been increasing in recent years. To …

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RNA methylation kit
Regulatory RNATools & Technology

New Kit Available to Study RNA Methylation

While the presence of 5-methylcytosine (5-mC) in RNA has been known for some time, the lack of methods available to study this epigenetic modification has made it challenging to elucidate its function. However, the new EZ RNA Methylation Kit from Zymo Research changes everything.  The EZ RNA Methylation Kit is …

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NSun2 and RNA methylation
Regulatory RNATools & Technology

More Methylation in RNA!?! RNA Continues to Surprise…

While DNA methylation is an extensively-studied epigenetic modification, relatively little is known about the methylation of cytosine bases in RNA.  Although the functional consequences of RNA modifications are not clear, RNA molecules are known to be extensively modified.  In fact, there are over 100 reported modifications to RNA, which is …

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cytosin-methylation-in-long-non-coding-rnas
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsImprinting and InheritanceRegulatory RNA

Old Dog, New Tricks? Cytosine Methylation in Long Non-Coding RNAs

Cytosine methylation (5-mC) in DNA is very common, and is generally associated with repression of gene expression.  DNA methylation was the first discovered type of epigenetic modification and remains one of the most actively investigated epigenetic processes, especially with respect to its use as a valuable biomarker for cancer and …

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shutterstock_103017095-[Converted]
Aging, Environment, & DiseaseRegulatory RNA

The Importance of Epigenetic Modification of RNA in miRNA Maturation and Breast Cancer

MicroRNAs (miRNAs) are single-stranded RNA molecules 18-24 bases in length that are important for the regulation of many biological processes by posttranscriptionally interfering with gene expression.   MiRNAs generally regulate gene expression by either facilitating mRNA degradation or repressing translation.  Generation of the mature and active form of miRNAs requires the …

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shutterstock_70581166
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Lost in translation? New findings suggest a critical role for cytosine methylation in tRNAs

While cytosine methylation in the DNA context will continue to be an important marker for epigenetic discoveries, current trends in the cytosine methylation game indicate diverse and critical roles of the modification in the RNA context. Much attention has been paid recently to findings in mRNA methylation, suggesting an important …

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