Low HDAC3 Expression Leads to Endometriosis-Linked Infertility
Aging, Environment, & DiseaseHistone Modifications

Low HDAC3 Expression Leads to Endometriosis-Linked Infertility

From fostering the development of new life to literally pushing out a 6 to 10-pound baby, the uterus is a pretty phenomenal organ. Every month it thickens its endometrial cells, the cells that line the inner wall of the uterus, in preparation for implantation of an embryo. But, if implantation …

READ MORE →
DNA methylation in the placenta
Developmental Biology & Stem CellsDNA Methylation and HydroxymethylationUncategorized

DNA Methylation in the Placenta: accelerated aging in pregnancy complications

The placenta is a unique organ as it is an extra-embryonic tissue primarily regulated by the fetal genome and shared between mother and fetus. However, it is a transient organ that is only needed throughout pregnancy and gestation and then is discarded after delivery. The essential role of the placenta …

READ MORE →
shutterstock_127766126
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Epigenetic Mechanisms Underlying Fetal Alcohol Spectrum Disorders

Alcohol consumption during any stage of pregnancy has been shown to result in a range of congenital and cognitive defects, collectively known as fetal alcohol spectrum disorder (FASD). Alcohol (EtOH) consumed by the mother is readily able to cross the placenta where it remains trapped in the amniotic fluid resulting …

READ MORE →