Mapping the Chromatin Landscape of Cancers
Aging, Environment, & DiseaseChromatin StructureTools & Technology

Mapping the Chromatin Landscape of Cancers

A betrayal of our own cells against us, cancer is a devastating disease that affects over 18 million people world-wide [1]. With more than 200 different types of cancer, most with diverse modes of action and variable outcomes among people, a deeper understanding of how different cancers function and progress …

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Epigenetic Diagnostics
DNA Methylation and HydroxymethylationTools & Technology

Epigenetic Diagnostics: Locus-specific DNA Methylation Testing Poised for Clinical Impact

Precision medicine holds great potential to make a direct positive impact in the clinic. A growing number of diagnostic panels addressing a list of disease indications are now available for testing. Currently most tests are designed for genetic analysis of sample DNA to help inform treatment decisions. With a few …

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DNA Methylation and Hydroxymethylation

Racial Differences in Healthy Breast Tissues: genome-wide methylation profiling and gene expression in healthy women

Racial differences in DNA methylation have been shown in breast cancers, but it remains unclear if these differences are present among healthy women. The study of normal tissues is distinguished from breast tumor study because it provides understanding of epigenetic predisposition that influences racial disparities in breast cancers. We performed …

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