Jeannie Lee lncRNA
Developmental Biology & Stem CellsImprinting and InheritanceRegulatory RNA

Reviewing the Roles of Long noncoding RNAs in Epigenetic Processes

Although RNA has traditionally been thought to act primarily as an intermediate between DNA and protein in the central dogma of molecular biology, these important molecules have received more attention in the last few years for their ability to carry out a wide variety of biological processes, including epigenetic regulation …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

A new web-based tool for high-throughput DNA methylation pathway analysis of multiple cancer types

Global cytosine hypomethylation and promoter hypermethylation are characteristic in cancer, but how DNA methylation targets biological pathways and gene sets is unclear. It is hypothesized that during tumorigenesis certain pathways and gene sets are commonly dysregulated via DNA methylation across cancer types. A logistic regression-based gene set enrichment method called …

Chromatin StructureDevelopmental Biology & Stem CellsHistone Modifications

Chromatin Density Matters

Histone methylation mediated by polycomb repressive complex 2 (PRC2) is involved in numerous biological processes, including cell differentiation, proliferation, and stem cell plasticity. Enhancer of Zeste homolog 2 (Ezh2), a subunit of PRC2, is a histone methyltransferase that specifically methylates histone H3 on lysine 27 (H3K27) and regulates polycomb gene …

Skeletal muscles affected by FSHD
Aging, Environment, & DiseaseRegulatory RNA

Epigenetic regulation of a non-coding RNA implicated in FSHD pathogenesis

Facioscapulohumeral muscular dystrophy (FSHD) is a common and debilitating myopathy very frequently associated with decreased D4Z4 repetitive element copy number at chromosome 4q35. The exact molecular mechanism driving FSHD is unknown, however, epigenetic dysregulation is suspected to be a major contributing factor.