Mitochondrial epigenetics neurodegeneration
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

READ MORE →
shutterstock_94771405
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNA

Epigenetics, Aging, and Neurodegeneration

Roy Lardenoije, Daniël van den Hove, and Bart Rutten Epigenetics is a booming, but highly complex and rapidly evolving field. Apart from the well-studied regulatory mechanisms involving DNA and histone modifications, and non-coding RNAs, there are the more recent additions of RNA methylation and editing, and reports of epigenetic regulation …

READ MORE →