ncRNA is Synergistically Regulated by Various Epi-Modifications
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNATools & Technology

Non-coding RNA Expression is Synergistically modulated by Various Types of Epigenetic Modifications

It is well known that most of the mammalian genome is transcribed, producing large amounts of non-coding RNAs (ncRNAs). The two main types of ncRNA are micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs are a recently discovered and well-characterized class of ncRNAs that are frequently dysregulated in different …

Regulatory RNA

Enhancer RNAs as molecular traps

Results from ENCODE released in 2007 suggested that 80% of the human genome plays a role in at least one RNA biochemical and/or chromatin modelling event; much higher than previously understood. More importantly, a significant portion of this active genome is transcribed into RNA, without any known corresponding functional protein. …

Aging, Environment, & DiseaseRegulatory RNA

Genome-Wide DNA Methylome Analysis Reveals Epigenetically Dysregulated Non-coding RNAs in Human Breast Cancer

Yongsheng Li, Yunpeng Zhang, Shengli Li, Jianping Lu, Juan Chen, Yuan Wang, Yixue Li, Juan Xu, Xia Li The development of human cancer is mediated by both genetic and epigenetic alterations of the cell. Since the discovery of altered DNA methylation in human cancer, DNA methylation studies of cancer have …

Chromatin StructureDevelopmental Biology & Stem CellsRegulatory RNA

Role Reversal: Are Transcription Factors Responsible for Heterochromatin Formation?

Regions of eukaryotic chromosomes are classified into two distinct groups: euchromatin, which is generally less compacted and contains actively transcribed genes, and heterochromatin, which is typically more compacted and contains silent genes and the majority of the repeated DNA elements.  Transcription factors are generally thought of as proteins that are …