Autism Awareness Month
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

April is Autism Awareness Month: Increased levels of 5-hmC may influence gene regulation in Autism Spectrum Disorder

The prevalence of Autism Spectrum Disorder (ASD) has increased by roughly 30% since 2012. The CDC recently reported that one in 68 children in the United States is affected by ASD, compared to one in 88 just two years ago. This enhanced occurrence could be attributed to advancements in the …

DNA hydroxymethylation and neuron development
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

DNA Hydroxymethylation and Neuron Development

It has been well known for many years that DNA methylation plays many roles in gene regulation and can direct different cell pathways such as apoptosis, differentiation, cancer, and aging. Although DNA methylation can be extremely stable – able to persist through multiple generations – it can also be quite …

Epigenetics of Hamster Reproduction
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Fall is in the Air: DNA Methylation Regulates Seasonal Hormonal Changes in Hamsters.

Ah the fall…the leaves are changing color, you can feel a chill in the air, the days are getting shorter, and your libido is decreasing…wait, what?!?  Well, maybe not in humans, but seasonal changes that affect the length of day, or photoperiod, can have a profound effect on reproductive behavior …

Epigenetics and PTSD
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Connecting Epigenetics and Memory to PTSD

1 in 5.  That is the statistic for Iraq and Afghanistan war veterans that have been diagnosed with Post-Traumatic Stress Disorder (PTSD), according to the Department of Veteran Affairs. PTSD is a severe psychological condition that can develop after witnessing traumatic events, and its symptoms include disturbing flashbacks, anxiety, distress, …

NSun2 and RNA methylation
Regulatory RNATools & Technology

More Methylation in RNA!?! RNA Continues to Surprise…

While DNA methylation is an extensively-studied epigenetic modification, relatively little is known about the methylation of cytosine bases in RNA.  Although the functional consequences of RNA modifications are not clear, RNA molecules are known to be extensively modified.  In fact, there are over 100 reported modifications to RNA, which is …

fist bump
Developmental Biology & Stem CellsDNA Methylation and HydroxymethylationImprinting and Inheritance

Yet Another Reason to Thank Dad This Father’s Day! Evidence for Paternally-Inherited Epigenetic Modifications

Maternal health during gestation and prenatal conditions are well documented as having profound effects on health and development of a baby after birth. The mechanisms behind many of these effects are attributed to epigenetic changes that take place in utero. More recently, pre-fertilization maternal health has been also been implicated …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Does Loss of DNA Methylation and Hydroxymethylation in the Brain Lead to Loss of Memory?

5-methylcytosine (5-mC) and 5-hydroxymethycytosine (5-hmC) are two major epigenetic modifications of DNA.  Dynamic changes in 5-mC and 5-hmC levels are tightly regulated and impact neural cell development, differentiation, and other biological functions. Deregulation of 5-mC and 5-hmC has also been implicated in various human diseases. However, whether 5-mC and 5-hmC …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

Put down that water bottle! BPA Exposure Alters Epigenetic Profile in Neurons

Bisphenol A (BPA) is an industrial chemical that is present in many consumer products, including plastic bottles and other food and beverage containers.  Although BPA has been used routinely since the 1960s, exposure to BPA has recently gained a lot of attention due to its proposed effect on brain development. …