Acetylation in Alzheimer's disease
Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Dysregulation of Histone Acetylation in Alzheimer’s Disease

In Alzheimer’s disease (AD) pathology, neuronal histone acetylation is reduced at memory-related genes [1]. Nativio et al specifically researched H4K16ac, a regulator of chromatin compaction, because it plays an important role in cellular aging and senescence [2]. By comparing the genome-wide profiles of H4K16ac in brain tissues from AD patients …