Sex Influences Brain Aging by Impacting DNA Methylation
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Sex Influences Brain Aging by Impacting DNA Methylation

While sex differences across aging and in the incidence of neurodegenerative diseases are well documented, relatively little data is available that compares sex-specific epigentic changes in the aging brain.1  Recent studies have identified specific loci with age-realted hyper- or hypo- methylation changes in liver, lung, and heart – but no …

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Mitochondrial epigenetics neurodegeneration
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

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Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNA

Epigenetics, Aging, and Neurodegeneration

Roy Lardenoije, Daniël van den Hove, and Bart Rutten Epigenetics is a booming, but highly complex and rapidly evolving field. Apart from the well-studied regulatory mechanisms involving DNA and histone modifications, and non-coding RNAs, there are the more recent additions of RNA methylation and editing, and reports of epigenetic regulation …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Does Loss of DNA Methylation and Hydroxymethylation in the Brain Lead to Loss of Memory?

5-methylcytosine (5-mC) and 5-hydroxymethycytosine (5-hmC) are two major epigenetic modifications of DNA.  Dynamic changes in 5-mC and 5-hmC levels are tightly regulated and impact neural cell development, differentiation, and other biological functions. Deregulation of 5-mC and 5-hmC has also been implicated in various human diseases. However, whether 5-mC and 5-hmC …

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