Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

How Environment Shapes Our Epigenome

Global mapping of the human epigenome has revealed that normal somatic cells exhibit their own unique DNA methylation patterns1. This tissue-specific methylome is established during development and faithfully maintained through subsequent cell divisions, in a process mediated by the enzymes DNMT1 and DNMT3A6. In recent years, there has been a …