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Aging, Environment, & DiseaseRegulatory RNA

Genome-Wide DNA Methylome Analysis Reveals Epigenetically Dysregulated Non-coding RNAs in Human Breast Cancer

Yongsheng Li, Yunpeng Zhang, Shengli Li, Jianping Lu, Juan Chen, Yuan Wang, Yixue Li, Juan Xu, Xia Li The development of human cancer is mediated by both genetic and epigenetic alterations of the cell. Since the discovery of altered DNA methylation in human cancer, DNA methylation studies of cancer have …

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5-methylcytosine (5-mC) in RNA
Developmental Biology & Stem CellsRegulatory RNA

5-Methylcytosine in RNA is More Common and Widespread than Previously Known!

The existence of 5-methylcytosine (5-mC) in nucleic acid has been known for more than 50 years, and the majority of research in the past has focused on 5-mC in DNA. However, 5-mC is also present in RNA and interest in this RNA modification has been increasing in recent years. To …

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NSun2 and RNA methylation
Regulatory RNATools & Technology

More Methylation in RNA!?! RNA Continues to Surprise…

While DNA methylation is an extensively-studied epigenetic modification, relatively little is known about the methylation of cytosine bases in RNA.  Although the functional consequences of RNA modifications are not clear, RNA molecules are known to be extensively modified.  In fact, there are over 100 reported modifications to RNA, which is …

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cytosin-methylation-in-long-non-coding-rnas
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsImprinting and InheritanceRegulatory RNA

Old Dog, New Tricks? Cytosine Methylation in Long Non-Coding RNAs

Cytosine methylation (5-mC) in DNA is very common, and is generally associated with repression of gene expression.  DNA methylation was the first discovered type of epigenetic modification and remains one of the most actively investigated epigenetic processes, especially with respect to its use as a valuable biomarker for cancer and …

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miRNA_3
Developmental Biology & Stem CellsRegulatory RNA

Soaking up the Competition – Circular RNAs as Molecular Sponges for miRNAs

Numerous families of non-coding RNAs have been identified in mammalian cells, including lncRNA, miRNA, siRNA, and piRNA.  Another type of RNA called circular RNA (circRNA) has remained a mysterious class, as the exact function of these molecules has not been described. Usually, circRNAs result from spicing events and have been …

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Jeannie Lee lncRNA
Developmental Biology & Stem CellsImprinting and InheritanceRegulatory RNA

Reviewing the Roles of Long noncoding RNAs in Epigenetic Processes

Although RNA has traditionally been thought to act primarily as an intermediate between DNA and protein in the central dogma of molecular biology, these important molecules have received more attention in the last few years for their ability to carry out a wide variety of biological processes, including epigenetic regulation …

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Skeletal muscles affected by FSHD
Aging, Environment, & DiseaseRegulatory RNA

Epigenetic regulation of a non-coding RNA implicated in FSHD pathogenesis

Facioscapulohumeral muscular dystrophy (FSHD) is a common and debilitating myopathy very frequently associated with decreased D4Z4 repetitive element copy number at chromosome 4q35. The exact molecular mechanism driving FSHD is unknown, however, epigenetic dysregulation is suspected to be a major contributing factor.

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