Sperm transfer aged epigenome to offspring
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Advanced Paternal Age at Conception Increases Risk of Age-Related Diseases in Offspring

As a person ages, they become more prone to diseases, including cancer and neurodegeneration. Having children when you are older can also affect the health of your offspring, increasing the risk for neuropsychiatric disorders, among many others [1], [2]. Sperm contribute epigenetic information to the zygote [3] that can affect …

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