Mitochondrial epigenetics neurodegeneration
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Mitochondrial Epigenetics and Neurodegeneration

Mitochondrial impairment is a feature of neurodegeneration and many investigators have suggested that epigenetic modifications of the mitochondrial DNA (mtDNA) might occur in Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative conditions, but evidence in humans is limited. There is accumulating evidence of epigenetic modifications in samples from patients …

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mitochondrion2
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

Mitochondrial epigenetics: Effects beyond the nuclear genome

  From playing a role in heritable changes to somatic mutations, including associations with diet, exercise, and other lifestyle interventions, epigenetics is progressively becoming implicated in a wide variety of activities and diseases. While the role of epigenetics has been predominately thought of in terms of genomic DNA, a clear …

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