Stem Cell Cultures
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Differing culture conditions can lead to both reversible and irreversible changes in DNA methylation.

Investigation into the mechanisms of pluripotency in stem cells and their potential applications is ongoing.  It is of utmost importance that these cells be propagated stably, both for the consistency of data within the scientific community and then also for potential clinical applications.  How do culture conditions impact methylation and …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Epigenetic Regulation is Involved in Host Antiviral Defense Mechanisms

Influenza is the virus that causes the flu, and can result in serious, sometimes fatal infections.  Influenza virus is easily transmitted within a population raising concerns of it causing an epidemic, or worse, a pandemic.  In recent years, the highly pathogenic H5N1 and H1N1 viruses have caused thousands of deaths …

Brown Mouse
Regulatory RNA

RNA methylation recently found to be a widespread epigenetic modification

DNA methylation is one of the most important and most intensively studied areas of epigenetic regulation.  However, there is not much known about the methylation of RNA molecules and whether RNA methylation is an epigenetic mechanism to regulate gene expression or other cellular processes.  RNA can be methylated at the …