DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity.
DNA Methylation and HydroxymethylationImprinting and Inheritance

De Novo DNA Cytosine Methyltransferase Enzyme Dynamics

The DNA methyltransferases (DNMT) are one busy enzyme family! While they are responsible for establishing and maintaining the mammalian cytosine methylome, they aren’t one and the same, as they take on some diverse roles. The DNMTs can from complexes with more than one DNMT to accomplish additional functions and their …

DNA Methylation and HydroxymethylationTools & Technology

An epigenetic platform to study global DNA methylome and transcriptome in parallel from limited tissue such as early embryo

Recent technological advances and the exponential growth of the field of epigenetics, in particular genome-wide studies, are advancing our knowledge and providing more evidence for the interdependence of epigenetic and genetic variations. The importance of genome-wide epigenetic reprogramming in mammalian germ cells and early embryos has shed light on the …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

How Environment Shapes Our Epigenome

Global mapping of the human epigenome has revealed that normal somatic cells exhibit their own unique DNA methylation patterns1. This tissue-specific methylome is established during development and faithfully maintained through subsequent cell divisions, in a process mediated by the enzymes DNMT1 and DNMT3A6. In recent years, there has been a …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Digging for Answers: The Potential of Curcumin as an Epigenetic Therapeutic Drug to Treat Cancer

The brilliant golden powder of turmeric is best known as the main spice in curry, but has also been widely used for many years in Eastern traditional medicines as an anti-inflammatory agent.  Turmeric has been used as an alleviator for arthritis, stomach pain, and cancer, among many other health issues. …