Colorectal cancer and obesity
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Risk for Colorectal Cancer is Increased by Obesity-related Gene Expression Changes

Colorectal cancer is an age-related disease traditionally seen in populations over the age of 50. In recent years, colorectal cancer has become more prevalent in younger individuals, and obesity is thought to be a major risk factor. However, the molecular mechanisms underlying this increased risk remains unclear. Since DNA methylation …

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mitochondrion2
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

Mitochondrial epigenetics: Effects beyond the nuclear genome

  From playing a role in heritable changes to somatic mutations, including associations with diet, exercise, and other lifestyle interventions, epigenetics is progressively becoming implicated in a wide variety of activities and diseases. While the role of epigenetics has been predominately thought of in terms of genomic DNA, a clear …

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This one goes with the war theme!
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

The Battle for HOXC10 in the War Against Breast Cancer

Tamoxifen and aromatase inhibitors (AIs) are both treatment options for patients with breast tumors that express estrogen receptor (ER) α and that require estrogen for growth. Tamoxifen competes with estrogen in binding to the ER, but does not activate the receptor. In comparison, AIs lower estrogen levels in the body …

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