Potential Treatment for Rett Syndrome Through Maintenance of X-inactivation
Aging, Environment, & DiseaseChromatin StructureDNA Methylation and Hydroxymethylation

Maintenance of X-inactivation: A Step Towards a Potential Treatment for Rett Syndrome

Not only do the brown and black splotches of fur on calico cats make them pretty cute, they also reflect a moment early in mammalian development called X-chromosome inactivation. While females have two X-chromosomes, males only have one, so to ensure that the expression of genes on the X-chromosome is …

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Aging, Environment, & DiseaseChromatin StructureDNA Methylation and Hydroxymethylation

Does defective binding of 5-hmC by MeCP2 contribute to Rett syndrome?

DNA methylation is an epigenetic modification that plays an important role in gene expression. Aberrant changes of DNA methylation in the genome are associated with many epigenetic-related neurological disorders. However, the mechanism by which DNA methylation affects chromatin structure and gene expression is not completely understood. Methyl-CpG-binding protein 2, (MeCP2), …

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