ncRNA is Synergistically Regulated by Various Epi-Modifications
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNATools & Technology

Non-coding RNA Expression is Synergistically modulated by Various Types of Epigenetic Modifications

It is well known that most of the mammalian genome is transcribed, producing large amounts of non-coding RNAs (ncRNAs). The two main types of ncRNA are micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs). MiRNAs are a recently discovered and well-characterized class of ncRNAs that are frequently dysregulated in different …

Aging, Environment, & DiseaseRegulatory RNA

Long Non-Coding RNAs Epigenetically Modify Brain and Behavior

Once considered vestiges of our evolutionary history associated with junk DNA, non-coding RNAs have emerged as important regulators of epigenetic processes, transcriptional activation, and posttranscriptional gene silencing. Advances in RNA sequencing (RNA-seq) technology have resulted in the discovery of a large number of long non-coding RNAs (lncRNAs), with many expressed …