Aging, Environment, & DiseaseTools & Technology

Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Neurodegeneration Therapy

Epigenetics play an important role in the proliferation and differentiation of stem cells, such as bone marrow derived mesenchymal stem cells (BM-MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). These stem cells can be epigenetically modified by introducing various factors into their culture media or growth environment …

Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

DNA Methylation and Hydroxymethylation in Stem Cells

Ying Cheng, Nina Xie, Tao Wang Stem cells, including embryonic stem cells (ESCs) and adult stem cells (ASCs), are undifferentiated cells that can differentiate into specialized cells and self-renew through mitosis. These stem cell identities and functions are highly controlled by epigenetic regulation, including DNA methylation, histone modifications and nucleosome …