DNA Methylation and Immune Cell Differentiation
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

DNA Methylation Regulates Differentiation of Naive Immune Cells into Effector Cells

During an adaptive immune response, naive CD8 T cells differentiate into antigen-specific effector cells that release cytotoxic proteins and rapidly proliferate to kill infected cells. When the pathogen has cleared, the majority of effector cells undergo apoptosis while a selected pool becomes memory cells. The differentiation process from naive to …

Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Epigenetic Regulation is Involved in Host Antiviral Defense Mechanisms

Influenza is the virus that causes the flu, and can result in serious, sometimes fatal infections.  Influenza virus is easily transmitted within a population raising concerns of it causing an epidemic, or worse, a pandemic.  In recent years, the highly pathogenic H5N1 and H1N1 viruses have caused thousands of deaths …