Neurodegeneration
Aging, Environment, & DiseaseTools & Technology

Epigenetics in Stem Cell Proliferation and Differentiation: Implications for Neurodegeneration Therapy

Epigenetics play an important role in the proliferation and differentiation of stem cells, such as bone marrow derived mesenchymal stem cells (BM-MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs). These stem cells can be epigenetically modified by introducing various factors into their culture media or growth environment …

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HUNTINGTON’S DISEASE
Aging, Environment, & DiseaseHistone Modifications

A Consistent Signature of Histone Deacetylation in Huntington’s Disease?

Huntington’s disease (HD) is a fatal neurodegenerative disorder that affects 5 to 10 people per 100,000 inhabitants. Despite the identification of the primary cause of the disease 20 years ago (an aberrant expansion of trinucleotide CAG repeats in the exon 1 of the huntingtin gene), there is still no effective …

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Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNA

Epigenetics, Aging, and Neurodegeneration

Roy Lardenoije, Daniël van den Hove, and Bart Rutten Epigenetics is a booming, but highly complex and rapidly evolving field. Apart from the well-studied regulatory mechanisms involving DNA and histone modifications, and non-coding RNAs, there are the more recent additions of RNA methylation and editing, and reports of epigenetic regulation …

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