Tools & Technology

Initial ENCODE Project Data Published!

The human genome project revealed the sequence of the roughly 3 billion DNA bases and approximately 25,000 genes found within our cells.  But exactly how that information is interpreted to, for example, be able to produce the nearly 300 distinct cell types found in the human body is still unknown. …

Aging, Environment, & DiseaseHistone ModificationsTools & Technology

Discovery of the first chemical inhibitor of histone demethylation

The study of post-translational modification of histone tails represents one of the largest areas of research in the field of epigenetics.  An improved understanding of how these modifications are added, recognized, and removed is essential to understand the mechanisms underlying epigenetic-based human diseases and to allow for the discovery of …

5mC and 5hmC
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Maternal instincts: Protection of 5mC?

DNA modification by 5-methylcytosine (5mC) was the only recognized DNA modification for many years in mammals and 5mC plays important roles in cell differentiation and development. Recently, a novel 5-hydroxymethylcytosine (5hmC) DNA modification has been reported and the balance between 5mC and 5hmC in the genome is a critical step …

DNA methylation & histone modification
DNA Methylation and HydroxymethylationHistone ModificationsTools & Technology

Analyzing two epigenetic marks (DNA methylation and histone modification) by one sequencing run

Epigenetic regulation is a complicated network involving DNA methylation, histone modification and non-coding RNAs, which all play in concert to control the epigenetic machinery. The cross talk between DNA methylation and histone modification is one of the most important interactions in establishing the epigenetic signature and was traditionally studied using …

The kidneys are responsible for salt reabsorption in the body
Aging, Environment, & DiseaseHistone Modifications

Epigenetic and dietary regulation of salt-sensitive hypertension

Hypertension (also known as high blood pressure) is a disease that is often heritable and can be a direct consequence of dietary factors.  A high intake of dietary salt is one factor that can potentially affect the expression of genes involved in regulating blood pressure, and thus contributes to the …

Skeletal muscles affected by FSHD
Aging, Environment, & DiseaseRegulatory RNA

Epigenetic regulation of a non-coding RNA implicated in FSHD pathogenesis

Facioscapulohumeral muscular dystrophy (FSHD) is a common and debilitating myopathy very frequently associated with decreased D4Z4 repetitive element copy number at chromosome 4q35. The exact molecular mechanism driving FSHD is unknown, however, epigenetic dysregulation is suspected to be a major contributing factor.