Histones in Paternal Epigenetic Inheritance
Histone ModificationsImprinting and Inheritance

A Role for Histones in Paternal Epigenetic Inheritance

A group of children grew up in the same neighborhoods of Quebec in the late 1960’s, but only some of them would reach their fifth birthday. In one of the first studies of its kind, Fabia and Thuy combed through hospital records to ask what made these children different from …

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When the writing is wrong: PRMT5 histone methylation promotes invasivity and metastasis in a range of human cancers
Aging, Environment, & DiseaseHistone Modifications

When the writing is wrong: PRMT5 histone arginine methylation promotes invasivity and metastasis in a range of human cancers

Cancer metastasis occurs when cancer cells leave a primary tumor and invade other tissues. Generally, this leads to a poor prognosis for patients. Underlying epigenetic mechanisms of tumor progression are poorly understood but are of great interest for developing new approaches of treatment in the clinic. Cancer etiology is highly …

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The “neighborhood effect” in chromatin biology: TET proteins-mediated DNA demethylation reconfigures the “histone code” at CpG islands
DNA Methylation and HydroxymethylationHistone Modifications

The “neighborhood effect” in chromatin biology: TET proteins-mediated DNA demethylation reconfigures the “histone code” at CpG islands

A nucleosome is constituted by positively charged histone proteins and negatively charged DNA. Methylation as well as other covalent modifications on DNA and histones ( together also called epigenetic modifications or marks) play important roles in the regulation of chromatin structure and function. TET (Ten-Eleven Translocation) proteins were identified as …

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Oxidative Stress and Epigenetics: a Novel Link Established Through Histone Adduction
Aging, Environment, & DiseaseHistone Modifications

Oxidative Stress and Epigenetics: a Novel Link Established Through Histone Adduction

Damage to cellular macromolecules caused by reactive oxygen species (ROS) produced during oxidative stress contributes to the pathogenesis of many disease states. One target of ROS is the 1,4-diene structure of polyunsaturated fatty acids (PUFAs), which is highly susceptible to peroxidation. An important outcome of lipid peroxidation is the generation …

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Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Gene Transcription: Not Always Dictated by Histone Modifications!

The proper regulation of gene expression is of fundamental importance in the maintenance of normal growth and development.  Misregulation of genes can lead to such outcomes as cancer, diabetes and neurodegenerative disease.  A key step in gene regulation occurs during the transcription of the chromosomal DNA into messenger RNA by …

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DNA hydroxymethylation and neuron development
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

DNA Hydroxymethylation and Neuron Development

It has been well known for many years that DNA methylation plays many roles in gene regulation and can direct different cell pathways such as apoptosis, differentiation, cancer, and aging. Although DNA methylation can be extremely stable – able to persist through multiple generations – it can also be quite …

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Chromatin StructureHistone ModificationsTools & Technology

AACR Special Conference on Chromatin and Epigenetics in Cancer

The advancements in Next-Generation sequencing technology have recently helped researchers uncover the importance of epigenetic modifying enzymes in many human cancers.  Numerous different cancer cells contain mutations in genes that encode histone-modifying enzymes and chromatin-remodeling factors, leading scientists and doctors to conclude that misregulated epigenetic processes are of central importance …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Down the Drain? 1MNA Acts as a Potent ‘Methylation Sink’ in Cancer Cells

The cancer field consistently proves to be one of the most critical areas for investigations into mechanisms governing tight epigenetic regulation, as nearly all types of cancers demonstrate misregulated epigenetic patterns. Most studies focus on the final epigenomic landscape in terms of histone and DNA modifications and methylomes; relatively few, …

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