Acetylation in Alzheimer's disease
Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Dysregulation of Histone Acetylation in Alzheimer’s Disease

In Alzheimer’s disease (AD) pathology, neuronal histone acetylation is reduced at memory-related genes [1]. Nativio et al specifically researched H4K16ac, a regulator of chromatin compaction, because it plays an important role in cellular aging and senescence [2]. By comparing the genome-wide profiles of H4K16ac in brain tissues from AD patients …

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HDAC Inhibitors as a Treatment for Acute Myocardial Infarction
Aging, Environment, & DiseaseArticle SummariesHistone Modifications

HDAC Inhibitors as a Treatment for Acute Myocardial Infarction

Histone deacytylase (HDAC) inhibitors are gaining interest in the treatment of cardiovascular diseases for their ability to decrease the damage to heart tissue after an ischemic event [1]. Cardiovascular diseases increase HDAC activity, altering histone acetylation [6, 7]. HDAC inhibitors can be used to decrease these epigenetic changes caused by …

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Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc
Aging, Environment, & DiseaseHistone Modifications

Activated protein C ameliorates diabetic nephropathy (kidney disease) by epigenetically inhibiting the enzyme p66Shc

Activated protein C (aPC) is a serine protease that is lost during diabetes. Previously it has been shown that aPC protects against diabetic nephropathy (dNP)1, a progressive kidney disease caused by damage to the capillaries.  aPC’s cytoprotective effect in diabetic nephropathy may be related to its in vitro ability to …

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Epigenetic-metabolic axis in aging
Aging, Environment, & DiseaseHistone Modifications

Midlife crisis? Exploring the metabolic-epigenetic axis in “early” aging

Aging is characterized by a gradual and overall deterioration of our body’s function. The risk to suffer from maladies such as cancer, dementia, loss of muscles and others is greatly increased with the progression of aging. A substantial scientific effort and funding is channeled towards the understanding of molecular mechanisms …

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