Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

A new web-based tool for high-throughput DNA methylation pathway analysis of multiple cancer types

Global cytosine hypomethylation and promoter hypermethylation are characteristic in cancer, but how DNA methylation targets biological pathways and gene sets is unclear. It is hypothesized that during tumorigenesis certain pathways and gene sets are commonly dysregulated via DNA methylation across cancer types. A logistic regression-based gene set enrichment method called …