C. elegans Histone Methyltransferase Targets Regions to Silence
Developmental Biology & Stem CellsHistone Modifications

How a C. elegans Histone Methyltransferase Targets Regions to Silence

As an organism grows and develops, its cells are rapidly dividing and committing to different fates. Some, for example, will become immune cells, while others will become skin cells. What decides the different fates of these cells is how their genes are expressed. For example, to become a skin cell, …

Chromatin Structure

CTCF Tucks Genes Into Their Lamina Associated Beds

The circadian rhythm allows cells to synchronize across a 24-hour clock. When the clock is disrupted individuals become predisposed to complex diseases like cancer, psychiatric disorders, diabetes, and metabolic syndrome. During the ticking of the clock oscillations in the expression of a number of genes, for instance those involved in …

Histone ModificationsTools & Technology

Histone Cleavage Can Interfere with the Measurement of Downstream Modifications

Histone modifications are increasingly being used as biomarkers in molecular epidemiology studies. However, a recent report from researchers at Columbia University describes a distinct histone H3 cleavage product, identified by Western blot, in human peripheral blood mononuclear cells (PBMCs), which interferes with the measurement of certain histone modifications (Howe and …