Hypomethylation and Genetic Instability in Monosomy Blastocysts May Contribute to Decreased Implantation Potential
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Epigenetics of Early Pregnancy Loss: Hypomethylation and Genetic Instability May Contribute to Decreased Implantation Potential of Monosomy Blastocysts

Blair R. McCallie1,3, Jason C. Parks1,3, Alyssa L. Patton1, Darren K. Griffin3, William B. Schoolcraft2, Mandy G. Katz-Jaffe1,2 1 National Foundation for Fertility Research, Lone Tree, Colorado, 80124, United States of America, 2 Colorado Center for Reproductive Medicine, Lone Tree, Colorado, 80124, United States of America, 3 School of Biosciences, …

READ MORE →
Figure 1: Factors involved in impaired male infertility due to reproductive aging.
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsImprinting and Inheritance

Paternal Age and Epigenetics

Maternal aging has been shown to cause infertility, pregnancy complications, spontaneous abortion, congenital anomalies, and perinatal complications. However, the impact of paternal ageing on semen quality and reproductive function has still been controversial. To address this, Drs. Sharma, Professor Agarwal and their co-authors have extensively reviewed this conflict in an …

READ MORE →