Epigenetic Link to Recurrent Miscarriage
Aging, Environment, & DiseaseChromatin StructureDevelopmental Biology & Stem Cells

An Epigenetic Link to Recurrent Miscarriage

Miscarriage, or natural loss of a pregnancy, is a common reproductive problem and can be upsetting for families trying to have a child. Recurrent miscarriage (RM) – two or more miscarriages – often occur because of problems that arise very early in embryonic development. A common cause of RM is …

MicroRNAs Take Down Brain Cancer
Aging, Environment, & DiseaseRegulatory RNA

MicroRNAs Team Up to Take Down Brain Cancer

MicroRNAs are small but powerful molecules in the cell. Containing only around 22 nucleotides, these small RNA molecules are responsible for binding to and silencing messenger RNA sequences before they can be translated into proteins, and thus are incredibly important regulators of gene expression. MicroRNAs (miRs) often regulate the expression …

Aging Promotes Tissue Regeneration and Less Scar Formation
Aging, Environment, & DiseaseChromatin StructureHistone Modifications

Aging Promotes Tissue Regeneration and Less Scar Formation

If Harry Potter had been older during his confrontation with Voldemort, he may not have even gotten his famous scar. Dermatologists have long noted that skin wounds in elderly patients tend to heal with less scarring than those in younger patients [1]. Recent work from Nishiguchi et al shows that …

Basal Cell Carcinoma - cancer
Aging, Environment, & DiseaseTools & Technology

A New and Targetable Epigenetic Biomarker for the Most Common Cancer

Basal cell carcinoma (BCC) is the most common cancer in people of Caucasian descent. BCC affects 2-3.5 million Americans yearly, and in some countries such as Denmark, BCCs outnumber all other cancers combined. Most BCCs can be successfully treated with surgery, particularly using Mohs micrographic surgical techniques, but some BCC …

Histone ModificationsUncategorized

EZH2: A New Biomarker and Epigenetic Target for Retinoblastoma

Retinoblastoma (RB) is the most common primary eye cancer in children, the third most common cancer in infants younger than 1 year and accounts for 12% of all infantile cancers per year. RB can be blinding and lethal, and is caused by mutations in the tumor suppressor gene RB1. However, current …

Chromatin StructureDevelopmental Biology & Stem CellsHistone Modifications

Chromatin Density Matters

Histone methylation mediated by polycomb repressive complex 2 (PRC2) is involved in numerous biological processes, including cell differentiation, proliferation, and stem cell plasticity. Enhancer of Zeste homolog 2 (Ezh2), a subunit of PRC2, is a histone methyltransferase that specifically methylates histone H3 on lysine 27 (H3K27) and regulates polycomb gene …