Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Epigenetics of myotonic dystrophy type 1 (DM1): CpG methylation profile of the DMPK gene

Myotonic dystrophy type 1 (DM1, Steinert’s disease, OMIM 160900) is the most common form of adult-onset muscular dystrophy in humans, characterized by myotonia (prolonged muscle contractions), muscle weakness, cataract, cardiac disease, gastrointestinal abnormalities, and central nervous system dysfunction.1 The clinical spectrum of DM1 patients is highly variable including congenital and …