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Chromatin StructureDevelopmental Biology & Stem Cells

Of Mice and Men: The Evolution of Cis-Regulatory Elements

DNase Hypersenestive sites (DHSs) are regions within the genome that are susceptible to cleavage by the enzyme DNase I. These regions are susceptible because they lie in uncondensed regions of euchromatin and are readily accessible to the DNase enzyme. In vivo however, these regions are also accessible to regulatory proteins …

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An incursion into the epigenetic landscape of our ancestors
Developmental Biology & Stem CellsDNA Methylation and HydroxymethylationTools & Technology

An incursion into the epigenetic landscape of our ancestors

Studying the evolution of epigenetic regulation in humans has proved to be quite difficult due to the lack of ancient material. Together in collaboration, stem cell biologist, Eran Meshorer and computational biologist, Liran Carmel were able to circumvent this problem by analyzing the genomes of two archaic humans, a Neanderthal …

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