Tau on the Epigenome of Alzheimer’s Brains
Aging, Environment, & Disease

Untangling the Role of Tau on the Epigenome of Alzheimer’s Brains

Forgetting where you put your car keys or the address of your aunt’s house is pretty normal, but for people with Alzheimer’s disease, this kind of forgetfulness and memory loss is just the tip of the iceberg. As the neurons in the brains of these patients degenerate, their memory loss …

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Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and HydroxymethylationTools & Technology

Using Saliva to Measure the Brain: Translating A Salivary Diagnostic for Fetal Alcohol Exposure

The consumption of any amount of alcohol during pregnancy can cause fetal alcohol spectrum disorders (FASD). FASD is an umbrella term covering a wide range of exposures from prenatal alcohol exposure, with the most severe outcome termed Fetal Alcohol Syndrome (FAS). However, the spectrum is wide and with no lower …

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Developmental Biology & Stem CellsDNA Methylation and HydroxymethylationHistone ModificationsTools & Technology

The epigenome mapped in more than 100 tissues and cell types

A consortium of researchers published a description of 111 epigenetic maps produced as part of the Roadmap Epigenomics Program. A useful tool for understanding epigenetic changes associated with several conditions, such as Alzheimer’s disease, cancers or autoimmune disorders. In the body, most of the cells have identical genomes. But the …

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Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Plastics and the Epigenome

In recent years, there has been growing concern regarding the negative effects of compounds found in plastic products. BPA, the most widely publicized, is only one of many compounds, known to be endocrine disruptors, which are used in plastics. Exposure to endocrine disrupting chemicals has been linked to many diseases …

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Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

How Environment Shapes Our Epigenome

Global mapping of the human epigenome has revealed that normal somatic cells exhibit their own unique DNA methylation patterns1. This tissue-specific methylome is established during development and faithfully maintained through subsequent cell divisions, in a process mediated by the enzymes DNMT1 and DNMT3A6. In recent years, there has been a …

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