Aging, Environment, & DiseaseRegulatory RNA

Long Non-Coding RNAs Epigenetically Modify Brain and Behavior

Once considered vestiges of our evolutionary history associated with junk DNA, non-coding RNAs have emerged as important regulators of epigenetic processes, transcriptional activation, and posttranscriptional gene silencing. Advances in RNA sequencing (RNA-seq) technology have resulted in the discovery of a large number of long non-coding RNAs (lncRNAs), with many expressed …

Chromatin StructureDevelopmental Biology & Stem Cells

3D Chromatin Organization, Transcription, and Behavior

The chromosomes of differentiated cells contain heterochromatic and euchromatic compartments. Heterochromatin is highly condensed and associated with repressed transcription, whereas in euchromatin  transcription is generally active. Spatial organization of heterochromatin can vary vastly among different differentiated cell types1. In contrast to differentiated cells, embryonic stem cells contain only sparse heterochromatic …