Jeannie Lee lncRNA
Developmental Biology & Stem CellsImprinting and InheritanceRegulatory RNA

Reviewing the Roles of Long noncoding RNAs in Epigenetic Processes

Although RNA has traditionally been thought to act primarily as an intermediate between DNA and protein in the central dogma of molecular biology, these important molecules have received more attention in the last few years for their ability to carry out a wide variety of biological processes, including epigenetic regulation …

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scale
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

WHEN IT COMES TO CANCER DRUGS, SOMETIMES LESS IS MORE

The chemotherapeutic drug decitabine (DAC) and its analog azacitidine (AZA) are FDA approved to treat cancers of the blood, such as myelodysplastic syndromes and certain types of leukemias. In high concentrations, DAC and AZA cause acute DNA damage followed by cell death. Currently, both drugs are limited to treatment of …

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