Patient-derived tumor xenograft models (PDXs) for ovarian cancer
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

A Better Model System for Ovarian Cancer: Patient-derived tumor xenografts (PDXs) are suitable for epigenetic methylome-based cancer research

Ovarian cancer is the most lethal gynecologic malignancy. After epigenomic analysis of patient tumors, aberrant DNA methylation patterns are universally observed in the most abundant histological subtype of ovarian cancer, high-grade serous ovarian cancer (HGSOC). These epigenetic modifications like DNA methylation are known to frequently affect gene regulation involved in …

Tools & Technology

Epigenome Editing with CRISPR-dCas9, TALEs, and Zinc Fingers

With a reference epigenome on the horizon it has become apparent that an enormous amount of variation, both inherited and environmental, is responsible for the development of complex traits and diseases. While a catalogue of such alterations is invaluable to humanity, perhaps more valuable would be the ability to alter …

Chromatin StructureHistone ModificationsTools & Technology

AACR Special Conference on Chromatin and Epigenetics in Cancer

The advancements in Next-Generation sequencing technology have recently helped researchers uncover the importance of epigenetic modifying enzymes in many human cancers.  Numerous different cancer cells contain mutations in genes that encode histone-modifying enzymes and chromatin-remodeling factors, leading scientists and doctors to conclude that misregulated epigenetic processes are of central importance …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Want To Lose More Weight With Less Effort? Epigenetics Can Help.

Genetic and lifestyle factors both play important roles in controlling our weight, and epigenetics has recently emerged as a powerful new tool to study the effects of lifestyle on obesity. Epigenetic mechanisms regulate heritable patterns of gene expression without changes in the DNA sequence through numerous processes, including DNA methylation …

Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Digging for Answers: The Potential of Curcumin as an Epigenetic Therapeutic Drug to Treat Cancer

The brilliant golden powder of turmeric is best known as the main spice in curry, but has also been widely used for many years in Eastern traditional medicines as an anti-inflammatory agent.  Turmeric has been used as an alleviator for arthritis, stomach pain, and cancer, among many other health issues. …

Aging, Environment, & DiseaseHistone Modifications

Epigenetics of Cocaine Addiction: Your Brain on Drugs

The dramatic behavioral changes induced by cocaine, such as hyperactivity, are accompanied by post-translational modifications (PTMs) of histones. These modifications result in altered gene expression in the area of the brain known as the nucleus accumbens (NAc), which is associated with pleasure. Past research pointed to the use of histone …

Keystone image
Aging, Environment, & DiseaseChromatin StructureDNA Methylation and HydroxymethylationHistone ModificationsRegulatory RNATools & Technology

Summary of Keystone Symposium: Epigenetic Marks and Cancer Drugs

In order for each of the cells of our bodies to stay healthy, gene expression must be controlled in a tightly regulated fashion. DNA is packaged around histone proteins, and a diverse set of enzymes are responsible for adding or removing specific post-translational modifications, or epigenetic marks, to histone tails. …

Aging, Environment, & DiseaseChromatin StructureDNA Methylation and HydroxymethylationHistone ModificationsTools & Technology

Dietary Epigenetics, Chemoprevention, and Green Tea Cupcakes

EpiBeat is excited to have Nikki write this guest post for us!  Nikki started her blog Scientifically Delicious about a year ago to write about the intersection between two of her passions: science and cooking.  She uses her background in biology to explain recent news and findings about food and …