Histones in Paternal Epigenetic Inheritance
Histone ModificationsImprinting and Inheritance

A Role for Histones in Paternal Epigenetic Inheritance

A group of children grew up in the same neighborhoods of Quebec in the late 1960’s, but only some of them would reach their fifth birthday. In one of the first studies of its kind, Fabia and Thuy combed through hospital records to ask what made these children different from …

Chaperoning Histone Inheritance
Chromatin StructureImprinting and Inheritance

Chaperoning Histone Inheritance

One of the great mysteries of epigenetics is how histones, the eponymous beads on a DNA string, are divided onto newly synthesized DNA strands during cell division. Histones carry modifications that serve as important signals in determining gene expression, regulating developmental programs, and their alteration can even mark disease states …

Epibeat figure
Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsImprinting and Inheritance

Transgenerational Epigenetic Inheritance: Why should you care?

Transgenerational epigenetic inheritance (TEI) is a relatively recent concept that has a major role in biological processes. Although we are just starting to understand the role of TEI in human health, the implications seem enormous. Our recent article in Clinical Epigenetics summarizes evidence in animal models showing transgenerational phenotypes that …

Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Starting from Scratch: DNA Methylation Marks Erased Through 5-hmC in Primordial Germ Cells

A growing body of evidence indicates that ancestral environmental factors can influence the physiology and behavior of the offspring, a process known as epigenetic inheritance. However, in each generation the epigenetically inherited modifications are thought to be erased in cells called primordial germ cells (PGCs), the precursors to sperm and …