Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationImprinting and Inheritance

Early-Life Epigenetic Programming by Endocrine Disrupting Chemicals

     The ‘developmental origins of adult health and disease’ (DOHaD) hypothesis postulates that adverse influences early in development can program the risks for adverse health outcomes in adult life. In modern societies, exposure to man-made environmental contaminants is a potential risk factor for developmental programming of chronic disease. Endocrine-disrupting …

Prenatal exposure to mixtures of xenoestrogens and repetitive element
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Prenatal exposure to mixtures of xenoestrogens & repetitive element-DNA methylation changes in human placenta

Endocrine Disrupting Chemicals (EDCs) are molecules that are able to interact with the endocrine system of different species, including humans,  leading to hormonal dysregulation and potentially be involved in the occurrence of diseases that are increasing in prevalence such as cancer, childhood obesity, fertility problems and neurobehavioral abnormalities (Diamanti-Kandarakis et …