Epigenetic Link to Recurrent Miscarriage
Aging, Environment, & DiseaseChromatin StructureDevelopmental Biology & Stem Cells

An Epigenetic Link to Recurrent Miscarriage

Miscarriage, or natural loss of a pregnancy, is a common reproductive problem and can be upsetting for families trying to have a child. Recurrent miscarriage (RM) – two or more miscarriages – often occur because of problems that arise very early in embryonic development. A common cause of RM is …

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Losing Heterochromatin to Determine Cell Fate
Chromatin StructureDevelopmental Biology & Stem Cells

Losing Heterochromatin to Determine Cell Fate

In the moments after fertilization, the tiny mass that is the embryo sets in motion developmental programs that will transform it into a human being. One of the earliest steps in human development is the formation of the germ layers. Humans and other animals in the Chordata phylum, have three …

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Aging, Environment, & DiseaseDevelopmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

Seasons influence the methylation profiles of newborns: more evidence that mom’s diet during pregnancy has lasting effects in her offspring.

Metastable epialleles (ME) are gene alleles that are differentially expressed through epigenetic regulatory mechanisms. The DNA methylation status of an ME is established during embryonic development, and can be maintained later into life. The differential methylation of these MEs contribute to phenotypic diversity between individuals and provides an explanation for …

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