Epigenetics of Hamster Reproduction
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Fall is in the Air: DNA Methylation Regulates Seasonal Hormonal Changes in Hamsters.

Ah the fall…the leaves are changing color, you can feel a chill in the air, the days are getting shorter, and your libido is decreasing…wait, what?!?  Well, maybe not in humans, but seasonal changes that affect the length of day, or photoperiod, can have a profound effect on reproductive behavior …

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Erasing Breast Cancer
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Erasing Breast Cancer: miRNAs and Epigenetic Factors Play Key Roles in Aggressive Breast Cancer Mechanisms

Cancer research is perhaps the poster child for the importance of integrating epigenetic analyses into a disease model. As research in the epigenetics of cancer continues to grow, relationships between myriad epigenetic regulators can become quite clear. In a recent study by Pier Paolo Pandolfi and colleagues, epigenetic players including …

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Aging, Environment, & DiseaseChromatin StructureDNA Methylation and HydroxymethylationHistone ModificationsTools & Technology

Dietary Epigenetics, Chemoprevention, and Green Tea Cupcakes

EpiBeat is excited to have Nikki write this guest post for us!  Nikki started her blog Scientifically Delicious about a year ago to write about the intersection between two of her passions: science and cooking.  She uses her background in biology to explain recent news and findings about food and …

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scale
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationTools & Technology

WHEN IT COMES TO CANCER DRUGS, SOMETIMES LESS IS MORE

The chemotherapeutic drug decitabine (DAC) and its analog azacitidine (AZA) are FDA approved to treat cancers of the blood, such as myelodysplastic syndromes and certain types of leukemias. In high concentrations, DAC and AZA cause acute DNA damage followed by cell death. Currently, both drugs are limited to treatment of …

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Cognitive decline in the brain
Aging, Environment, & DiseaseDNA Methylation and Hydroxymethylation

Don’t forget about Dnmt’s

There is not a lot of knowledge about the enzymes that influence the molecular pathways underlying the normal aging process. A recent publication in Nature Neuroscience showed that the DNA methyltransferase Dnmt3a2 is critically involved in age-associated cognitive decline in mice. Oliveira et al.  found that up regulating Dnmt3a2 can …

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Mouse embryonic stem cells
Developmental Biology & Stem CellsDNA Methylation and Hydroxymethylation

How is DNA Methylation Maintained in ESCs and Differentiated Cells?

DNA methylation has been shown to be very important for development, differentiation, and aging.  But how is DNA methylation maintained?  When and how does de novo DNA methylation occur?  Are there specific DNA methyltransferases (Dnmts) involved in non-symmetric DNA methylation or DNA methylation outside of the CpG context?  There have …

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shutterstock_37909594
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationRegulatory RNA

Epigenetic Regulation is Involved in Host Antiviral Defense Mechanisms

Influenza is the virus that causes the flu, and can result in serious, sometimes fatal infections.  Influenza virus is easily transmitted within a population raising concerns of it causing an epidemic, or worse, a pandemic.  In recent years, the highly pathogenic H5N1 and H1N1 viruses have caused thousands of deaths …

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