Epigenetic Regulators Are Important for Maintaining Bone Homeostasis
Aging, Environment, & DiseaseDNA Methylation and HydroxymethylationHistone Modifications

Balancing Bones: Epigenetic Regulators Are Important for Maintaining Bone Homeostasis

Walking the dog is not typically considered a dangerous task, but when an unexpected tug on the leash leads to a fall and a broken hip, it certainly becomes one. As we age, the balance between the formation of new bone and the removal of old bone shifts. New bone …

Chromatin StructureDNA Methylation and Hydroxymethylation

Choosy DNA Methyltransferases Choose CpG-Dense Regions

While changes in DNA methylation have been implicated in a variety of diseases, there is still much to learn about the cellular regulation of DNA methylation patterns across the genome. De novo methyltransferases DNMT3A and B are known to establish DNA methylation. In a recent paper, Baubec et al. investigated …

DNMT3 is an enzyme from a group of DNA methlytransferases, which modify DNA in order to regulate gene expression and activity.
DNA Methylation and HydroxymethylationImprinting and Inheritance

De Novo DNA Cytosine Methyltransferase Enzyme Dynamics

The DNA methyltransferases (DNMT) are one busy enzyme family! While they are responsible for establishing and maintaining the mammalian cytosine methylome, they aren’t one and the same, as they take on some diverse roles. The DNMTs can from complexes with more than one DNMT to accomplish additional functions and their …